The ASPIS cluster—comprising ONTOX, PrecisionTox, and RISK-HUNT3R—is gearing up for an exciting presence at the 2025 Society of Toxicology (SOT) Annual Meeting and ToxExpo in Orlando, Florida! From 17 to 20 March 2025, ASPIS experts will showcase cutting-edge advancements in non-animal methodologies (NAMs) and next-generation risk assessment (NGRA).
The ASPIS cluster is at the forefront of developing next-generation chemical risk assessment approaches that reduce reliance on animal testing. Presentations and posters of ASPIS researchers will cover the latest advancements in NAMs, computational toxicology, exposure science, and regulatory frameworks. Attendees are invited to visit exhibitors, attend insightful presentations, and engage with ASPIS researchers at poster sessions.
Exhibitors at the ToxExpo
- ASPIS Booth #1362 – Discover the latest developments from ONTOX, PrecisionTox, and RISK-HUNT3R.
- MN-AM Booth #530 – Meet ONTOX partner Jörg Marusczyk, the developer of the ONTOX Hub and marketplace.
ASPIS Presentations and Posters at the US SOT
17 March 2025:
- 9:15-11:45 AM, Sector N686 (red): Marco Siccardi (ONTOX) – Advancing Maternal-Fetal PBK Models for Cross-Species Risk Assessment in Toxicology (poster)
- 9:20-9:45 AM, Room W307A: Nynke Kramer (ONTOX) – A Framework for Improving the Quality of In Vitro Toxicity Data for Quantitative In Vitro to In Vivo Extrapolation of “Difficult” Chemicals (presentation)
- 10:35 AM – 11:00 AM, Room W307A: Beate Escher (PrecisionTox) – Measuring and Controlling Exposure in Cell-Based Bioassays (presentation)
- 11:05-11:30 AM, Room W206A: Florian Caiment (ONTOX) – ’Omics Data and Regulatory Frameworks: Success and Challenges (presentation)
- 1:45-4:15 PM, Sector G368 (green): Hennicke Kamp (RISK-HUNT3R) – Assessment of the Robustness and Accuracy of the DIO1-SK Assay: A Comparative Analysis (poster)
- 1:45-4:15 PM, Sector B144 (blue): Marco Siccardi (ONTOX) – An EU strategy on aggregate exposure: The ExpoAdvance Roadmap (poster)
18 March 2025:
- 8:05-8:40 AM, Room W203A: Nynke Kramer (ONTOX) – Integrating In Vitro Biokinetics Tools into Next-Generation Risk Assessment Using the ASPA Workflow (presentation)
- 9:15 AM – 9:50 AM, Room W203A: Beate Escher (PrecisionTox) – Applicability Domain of PBK Models to Chemicals and Regulatory Challenges (presentation)
- 9:15-11:45 AM, Sector J516 (green): Marco Siccardi (ONTOX) – Purrfect fit: Validation of PK-Sim cat model for iv administration (poster)
- 9:15-11:45 AM, Sector J489 (green) Devon Barnes (ONTOX) – Development of an In Vitro Battery for Predicting Nephrotoxicity: Elucidating Early Onset Mechanisms of Kidney Toxicity (poster)
19 March 2025:
- 9:05-9:30 AM, Room W204A: Mathieu Vinken (ONTOX) – Effects of Altered Microgravity and Cosmic Radiation on the Liver (presentation)
- 1:45-4:15 PM, Sector D247 (orange): Helena Kandarova (ONTOX) – Occular irritation and photo-irritation testing of medical devices and drugs using 3D human reconstructed cornea-like tissue model (poster)
- 1:45-4:15 PM, Sector J531 (green): Hennicke Kamp (RISK-HUNT3R) – Assessing PPARα Agonist Activity and its Implications for Pancreatic Acinar Cell Tumor Development in Rats (poster)
- 1:45-4:15 PM, Sector J502 (green): Hennicke Kamp (RISK-HUNT3R) – A Weight of Evidence Review on the Mode of Action, Adversity, and the Human Relevance of Xylene’s Observed Thyroid Effects in Rats (poster)
- 1:45 PM–4:15 PM, Sector J519 (green): Maria Bondesson (PrecisionTox) – PFOA induces lipid species alterations in a pancreatic cancer zebrafish model (poster)
- 2:50-3:15 PM, Room W204A: Thomas Hartung (ONTOX) – The Use of AI in Safety Assessment of Medical Devices (presentation)
20 March 2025:
- 8:35-9:10 AM, Room W304E: Bernard Staumont (ONTOX) – Building Knowledge: Ontology Maps for Applications in Toxicology (presentation)
- 9:45-10:20 AM, Room W304E: Job Berkhout (ONTOX) – Toward a Virtual Embryo: A Dynamic Systems Model for the Prediction of Neural Tube Closure Defects (presentation)
